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YUI's App Framework suite of components does not currently have any data binding features, so the short answer would be no since MVVM patterns tout data binding.

That said, data binding is definitely something we'd like to add to the App Framework, being able to reduce common boilerplate code into conventional patterns is an obvious win.

MVP design patterns, a close cousin of MVVM, are possible and easily implementable using the current suite of components and features in the App Framework. I did a quick proof of concept implementing a Presenter which can be seen here:
https://github.com/yui/yui3/blob/master ... enter.html